Low Dose Naltrexone has been very much discussed lately because the word is out that it really helps with autoimmune diseases. Autoimmune diseases are associated with a malfunction of the immune system which causes the body to attack its own tissues instead of just foreign substances.



There are more than 80 types of autoimmune diseases affecting more than 50 million Americans of whom 75% are women. Symptoms associated with the autoimmune disease include inflammation, fatigue, muscle aches, low fever, swelling, redness, rash, diarrhea, stomach disorders and many more. Some of the more common autoimmune diseases are:


-Rheumatoid arthritis. The immune system attacks the joints causing pain and swelling.

-Lupus. Autoimmune antibodies attach to tissues throughout the body.

-Inflammatory bowel disease (IBD). The immune system attacks the lining of the intestines,

-Ulcerative colitis. IBD disease affecting the large colon.

-Crohn’s Dissease. IBD disease affecting the small intestines or entire GI tract.

-Irritable bowel syndrome (IBS). No inflammation but stomach pain, cramps, diarrhea.

-Multiple Sclerosis MS). The immune system attacks nerve cells causing weakness, muscle spasm, and poor coordination.

-Psoriasis. Immune attacks the skin producing scaly plaques on the skin.

-Graves disease. Immune system produces antibodies that stimulate the thyroid gland to overproduce excess amounts of thyroid hormone (hyperthyroidism).

-Hashimoto’s thyroiditis. Immune system produces antibodies that attack the thyroid gland destroying the cells that produce thyroid hormone. (hypothyroidism).

-And many more


The diagnosis and treatment of autoimmune diseases are both complicated and difficult to treat. Most medications at best give temporary symptom relief. The good news is that Naltrexone in low doses has a proven track record of having very positive outcomes with most autoimmune diseases. 



Naltrexone is classified as an opiate antagonist that binds to the opioid receptor. This effectively blocks the receptor, preventing the body from responding to opioid drugs. It is used to treat addiction to opiate drugs. The prescription drug comes in a tablet of 50mg and is used in a dose of 50mg to 300mg daily to completely block the opioid receptor.


In a low dose, usually 4.5mg a day, there is only temporary blockage of the opioid receptor.When the low dose wears off the body responds by producing thousands times more of the natural endorphins in the body. The increase in endorphins modulates the adverse immune response resulting in a dramatic improvement in autoimmune diseases. Studies and personal testimonials are proving that LDN may be the best answer to treating most autoimmune diseases.


LDN has very few if any side effects, is relatively inexpensive, and easy to take at once a day dosing usually at bedtime. LDN does require a prescription from your physician and is available at most compounding pharmacies. Your physician will start you at a lower dose, usually 1.5 mg, and increase at biweekly intervals until the maintenance dose of 4.5mg is reached.


Legacy Compounding has many patients taking LDN for autoimmune diseases with very favorable results. Refer to some of the testimonials on this website. If you have any questions or need more information please feel free to contact us.


Does LDN Really work for Autoimmune diseases?

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